楊勝祥，男，教授，浙江省高層次拔尖人才培養計劃入選者，植物資源與創新藥物化學課題組負責人。2011年獲得化學生物學博士學位。2010年1月-2011年10月，在國家留學基金委建設高水平大學項目的支持下，赴德國哥廷根大學化學系完成聯合培養博士生項目，師從國際著名天然藥物化學家Hartmunt Laatsch教授從事抗腫瘤先導化合物的研究。2013年在德國哥廷根大學Petr Karlovsky教授課題組開展新型mycotoxins的全合成及其構效關系研究工作。2014年9月-2015年9月韓國建國大學特邀講座教授交流一年。長期緻力于有機化學和天然藥物化學的教學和科研工作。楊勝祥老師主要從事天然藥物/産物方向的研究，研究領域主要包括天然活性物質的發現及其功能産品的開發、功能分子的“垂釣”技術、計算機輔助藥物設計以及新型植物激素獨腳金内酯的化學生物學研究。近5年來，先後主持和參與國家重點研發項目、中央本級重大增減支項目、國家自然科學基金、浙江省“領雁計劃”項目、浙江省自然科學基金及企業橫向項目等多項課題；申請國家發明專利和實用新型專利20餘項，授權發明專利5項，授權實用新型專利12項，發表SCI論文50餘篇。
近五年的代表性論文：
[1]Chenggang Song, Xing Wang, Jian Yang, Yi Kuang, Yuxuan Wang,Shengxiang Yang*, Jianchun Qin, Lanping Guo. Antifungal biphenyl derivatives fromSorbus pohuashanensisLeaves infected byAlternaria tenuissiand their effect against crop pathogens. Chemistry & Biodiversity, 2021, doi: 10.1002/cbdv.202100079.(通訊作者)
[2]Chen Yu Chao, Kuang Yi,Yang Shengxiang*, Yuan Yuan, Huang Luqi. Synthesis of new halogenated GR24analogues and their evaluation as germinationpromotors onOrobanche Cumana.Frontiers in Plant Science, 2021,doi:10.3389/fpls.2021.725949.(通訊作者)
[3]Lin Li-Bin,Jian Xiao,Qiang Zhang, Rui Han,Biao Xu,Sheng-Xiang Yang*, Wen-Bo Han*, Jiang-Jiang Tang, and Jin-Ming Gao*.Eremophilane Sesquiterpenoids with Antibacterial and Anti-inflammatory Activities from the Endophytic Fungus Septoria rudbeckiae.Journal of Agricultural and Food Chemistry, 2021, doi:10.1021/acs.jafc.1c04131.(通訊作者)
[4]Qing-LinMou,Sheng-Xiang Yang,TingXiang,Wen-WenLiu,JianYang,Lan-PingGuo,Wen-JingWang,Xiao-LongYang.New cytochalasan alkaloids and cyclobutane dimer from an endophytic fungusCytospora chrysospermainHippophae rhamnoidesand their antimicrobial activities.Tetrahedron Letters, 2021, doi:10.1016/j.tetlet.2021.153207.
[5]Kuang Yi, Kirstin Scherlach, Christian Hertweck,Shengxiang Yang*, Diego Sampietro, Petr Karlovsky. Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides. Mycotoxin Research, 2021, submitted. (通訊作者)
[6] Kuang Yi, Xiating Shen, Huiyi Xu,Shengxiang Yang*, Jian Yang, Diego Sampietro. Optimization of ultrasound-assisted aqueous two-phase system extraction of β-carotene from sweet potato roots by response surface methodology. Journal of Food Science, 2021, submitted. (通訊作者)
[7]Sheng-Xiang Yang, Ming-Sheng Bai, Jian Yang, Yuan Yuan, Ya-Mei Zhang,Jian-Chun Qin, Yi Kuang, Diego A. Sampietro.Chemical composition and larvicidal activity of essential oils from
Peganum harmala,Nepeta catariaandPhellodendron amurenseagainstAedes aegypti(Diptera: Culicidae).Saudi Pharmaceutical Journal, 2020, 28: 560-564.
[8]Sheng-Xiang Yang, Cheng-Gang Song, Yi Kuang, Bing Liu, Yan-Xin Zhang,Ming-Zhe Zhang, Chun-Ying Zhang, Gang Ding,Jian-Chun Qin.Cytotoxicactivity ofinositolangelates andTirucallane-typealkaloids fromAmoora Dasyclada.Molecules,2020, 25:1222-1228.
[9]Juan Yang, Xu Han, Hao-Yu Wang, Jian Yang, Yi Kuang, Kai-Yue Ji, Yi Yang, Kai Pang,
Sheng-Xiang Yang*, Jian-Chun Qin, Hong-Peng Wang.Comparison of metabolomics ofDendrobium officinalein different habitats byUPLC-Q-TOF-MS.Biochemical Systematics and Ecology,2020,89:104007-104012.(通訊作者)
[10]Sheng-Xiang Yang, Bing Liu, Mei Tang, Jian Yang, Yi Kuang, Ming-Zhe Zhang, Chun-Ying Zhang, Chao-Yi Wang, Jian-Chun Qin, Lan-Ping Guo, Li-Chun Chao.Extraction of flavonoids fromCyclocarya paliurus(Juglandaceae) leaves using ethanol/salt aqueous two-phasesystem coupled with ultrasonic. Journal of Food Processing and Presevation,2020;00:e14469.
[11]Sheng-Xiang Yang, Jian-Zhong Sun, Jian Yang, Yuan Yuan, Jian-Chun Qin,D.A. Sampietro.
Herbicidal, fumigant and insecticidal potential of essential oil from flowers ofBuddleja alternifoliaMaxim.Allelopathy Journal, 2020,51: 113-124.
[12]Sheng-Xiang Yang, Jing-Fang Xiao, Ting-Kai Liu, Ze-Diao Huang,Xiang Li, Ye-Miao Chen,and Xiao-Long Yang.A 3D screening approach identifies the compoundepitajixanthone hydrate as a new inhibitor of cancer cellgrowth and invasion.Anti-Cancer Drugs, 2019,DOI: 10.1097/CAD.0000000000000873.
[13]Sheng-Xiang Yang,Wen-Ting Zhao, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen, Jian Yang, Xiao-Long Yang.Aureonitols A-B, Twonew C13-Polyketides fromChaetomium globosum, anEndophytic Fungus inSalvia miltiorrhiza.Chemistry & Biodiversity, 2019, 16:e1900364.
近五年主持的代表性科研項目：
[1]新型獨腳金内酯類似物的合成及其對寄生植物種子生理的影響機制研究，中央本級重大增減支項目，100萬，2020.9-2023.9，主持；
[2]中草藥毒性藥材的基原調查及中草藥公共安全鑒定數據庫，國家重點研發計劃“科技基礎資源調查”專項，110萬，2019.1-2022.12，主持；
[3]植物内生真菌源氯代azaphilonoids類化合物的挖掘及其構效關系研究，浙江省公益研究計劃項目，10萬，2019.1-2021.12，主持；
[4]基于UPLC/Q-TOF-MS/MS技術對毛竹筍中新型植物内源激素獨腳金内酯類物質的挖掘及其構效關系研究，浙江省竹資源與高效利用協同創新中心項目，6萬，2018.12-2020.12，主持.
聯系方式：浙江杭州臨安武肅街666号bv伟德官方网站化學與材料工程學院
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