
趙偉 博士,中國藥理學會會員,主要從事基于離子通道的天然産物活性物質篩選與藥物安全性評價方面的研究。近年來,利用分子生物學與電生理學相結合的方法,我們建立了種類齊全的離子通道活性物質篩選平台。該平台涵蓋了人的心血管、免疫、痛覺、肌肉、神經、脾、肺、腎髒等相關的離子通道細胞株及藥物作用靶點的突變體。目前,我們已經利用該平台對上百種中藥及其主要成分的活性進行了篩選和研究,在浙貝母、厚樸、五味子、和狼毒等傳統中藥中發現了豐富的離子通道活性物質。先後主持或者參與國家973計劃,國家自然科學基金,浙江省基礎公益項目及bv伟德官方网站科研發展基金等多項。截止2019年5月已發表論文13篇,其中SCI收錄8篇。
論文和專利
1.Wei Zhao, Yuan Chen*. Progress in research of Kv1.1 and Kv1.3 channels as therapeutic targets. Current Topics in Medicinal Chemistry, 2016, 16(16): 1877-1885.
2.Jianwei Xu#, Wei Zhao#, Lanying Pan, Ailian Zhang, Qingmao Chen, Kai Xu, Haiyin Lu, Yuan Chen*, Peimine. a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia, 2016, 111: 1-6. (共同第一作者)
3.Jifeng Zheng#, Wei Zhao#, Kai Xu, Qingmao Chen, Yingying Chen, Yueliang Shen, Liping Xiao, Liqin Jiang*, Yuan Chen*. Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose. European Journal of Pharmacology, 2017, 800:23-33. (共同第一作者).
4.Liandi Kan#, Wei Zhao#, Lanying Pan, Jianwei Xu, Qingmao Chen, Kai Xu, Liping Xiao, Yuan Chen*. Peimine inhibits hERG potassium channels through the channel inactivation states. Biomedicine & Pharmacotherapy, 2017, 89:838-844. (共同第一作者)
5.Wei Zhao, Min Shi, Xiqian Ye, Fei Li, Xiaowei Wang, Xuexin Chen*. Comparative transcriptome analysis of venom glands from Cotesia vestalis and Diadromus collaris, two endoparasitoids of the host Plutella xylostella. Scientific Reports, 2017, 7:1298.
6.Wei Zhao, Min Shi, Xuexin Chen*. Immature morphology and development of Diadromus collaris (Hymenoptera: Ichneumonidae), an important endoparasitoid of Plutella xylostella (Lepidoptera: Plutellidae). Annals of the Entomological Society of America, 2014, 107(1): 234-241.
7.Zhizhi Wang, Min Shi, Wei Zhao, Qiaoli Bian, Gongyin Ye, Xuexin Chen*. Identification and characterization of defensin genes from the endoparasitoid wasp, Cotesia vestalis (Hymenoptera: Braconidae). Journal of Insect Physiology, 2013, 59(11): 1095-1103.
8.Yanyan Ren, Lanying Pan, Wei Zhao, Lei Xu, Jianwei Xu, Haiyin Lu, Yuan Chen*. Neochamaejasmin A inhibits Kv1.4 channel activity via direct binding to the pore. Brain Research, 2018 1683:17-26.
9.朱曉琳,陳淵,趙偉*,貝母素甲藥理作用的研究進展,藥物生物技術,2018,25(6):561-564. (通訊作者)
10.鐘點,陳淵,趙偉*,雷公藤紅素抗炎及免疫抑制的研究進展,藥物生物技術,2018,25(1):64-69. (通訊作者)
11.張燕婷,陳淵,趙偉*,紅黴素的心髒安全性研究進展,藥物生物技術,2018,25(2):166-170. (通訊作者)
12.趙偉, 劉強*. 中國特有植物四合木(Tetraena mongolica)昆蟲群落與多樣性特征. 應用昆蟲學報, 2010, 47(1): 177-182.
13.趙偉, 劉強*. 四合木(Tetraena mongolica)林地昆蟲群落的組成、結構及多樣性特征. 生态學雜志. 2011, 30(11): 2554-2561.
14.專利:陳學新,王知知,時敏,趙偉. 菜蛾盤絨繭蜂抗菌肽防禦素基因、抗菌多肽及應用. 專利号:ZL 2012 1 0315023.2.
聯系方式
郵箱:weizhao@zafu.edu.cn